Compared with graphene, GQDs have better water solubility, lower cytotoxicity [ 61 , 150 , 175 , 176 ], and larger specific surface area, which makes them more effective drug molecular ⦠Here, we used Pue-loaded graphene oxide (GO) nanosheets, which have an excellent drug-loading ability, modifiable surface functional groups, and good biocompatibility. By Dariane Jornada Clerici, Márcia Ebling de Souza, Book Nanoconjugate Nanocarriers for Drug Delivery. Advanced review of graphene-based nanomaterials in drug delivery systems: synthesis, modification, toxicity and application. Abstract. It has driven to cancer nanotechnology to defeat cancer therapy obstacles, via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier, and controllable release of anticancer drugs. Current research is developing practical applications of graphene for use in drug delivery, as a material for building biosensors, as a potential antibacterial agent and as a scaffold for tissue engineering. Comprehensive Review on Graphene Oxide for Use in Drug Delivery System. Abstract. Amongst multifaceted GO dynamics, in this review, attempts are made to discuss the advanced applications of GO or graphene-based materials (GBNs) in the biomedical field involving drug or therapeutic gene delivery, dual drug or drugâgene combination targeting, special delivery of drug cocktails to the brain, stimuli-responsive release of molecular payloads, and Janus-structured smart ⦠The findings, published in the journal ChemComm, build on existing knowledge about graphene. Graphene oxide (GO) is an amphiphilic, high surface area material with great potential as a functional excipient in drug delivery. Graphene or graphene-based nanomaterials [145, 172] have been reported for drug delivery and release in order to improve delivery efficiency and enhance therapeutic effects [143, 171,172,173,174]. The unmodified basal plane sites of graphene that has free surface Ï electrons are hydrophobic and are capable of forming ÏâÏ interactions for loading drug as well as covalent modifications [63, 64]. Although GO nano-colloids (GON) were proposed as drug release matrix for targeting cancer cells, there is still a concern regarding its cytotoxicity issues. Carbon Nanotubes (CNTs) and Graphene Have Attracted Tremendous Attention as the Most Promising Carbon Nanomaterials in the 21st Century for a Variety of Applications such as Electronics, Biomedical Engineering, Tissue Engineering, Neuroengineering, Gene Therapy and Biosensor Technology. With graphene droplets now easy to produce, researchers say this opens up possibilities for its use in drug delivery and disease detection. âFlying Carpetâ Technique Uses Graphene To Deliver One-Two Punch Of Anticancer Drugs An international team of researchers has developed a drug delivery technique that utilizes graphene strips as âflying carpetsâ to deliver two anticancer drugs sequentially to cancer cells, with each drug targeting the distinct part of the cell where it will be most effective. Abstract:Nano graphene oxide (nGO) is a member of graphene family, which is a novel, one-atom-thickness, two-dimensional carbon nanomaterial. Herein, a redoxâsensitive, hyaluronic acidâdecorated graphene oxide nanosheet (HSG) is developed for tumor cytoplasmâspecific rapid delivery using nearâinfrared (NIR) irradiation controlled endo/lysosome ⦠Graphene has also been reported to be efficiently taking up cancerous cells thereby enabling the design of drug delivery agents for cancer therapy. Click here to navigate to parent product. However, certain pathogens, viruses, and bacteria disrupt the endothelial barrier and cause infection and hence inflammation in meninges. Graphene for Drug Delivery: Focus on Antimicrobial Activity book. Graphene-based electroresponsive scaffolds as polymeric implants for on-demand drug delivery Adv Healthc Mater . Since the seminal report on use of graphene oxide (GO) as an efficient nanocarrier for drug delivery by Dai et al. The development of versatile nanoplatforms with efficient tumor-targeting properties and synergistic therapeutic strategies to realize effective antitumor efficiency are highly anticipated in the field of cancer therapy. Zhang Q, Wu Z, Li N, Pu Y, Wang B, Zhang T, et al. This review will focus on various synthesis and functionalization of graphene and graphene oxide for providing better solubility and targeted drug delivery at cancer cells. Recently, there has been enormous developments in the field of delivery systems to provide therapeutic agents or natural based active compounds to its target location for treatment of various aliments [33, 34].There are a number of drug delivery systems successfully employed in the recent times, however there are still certain challenges that need to be addresses and an advanced ⦠Graphene family nanomaterials, with superior mechanical, chemical, and biological properties, have grabbed appreciable attention on the path of researches seeking new materials for future biomedical applications. We also demonstrate the surface engineering and multifunctional modification of graphene, and further present the active role of rational decoration in drug delivery, therapy, and theranostic application. Graphene strips for anti-cancer drug delivery. Antiinflammatory drug delivery of ibuprofen has been reported by applying chitosan-containing GO . One of the earliest biomedical applications of graphene was for improved drug delivery. Macromolecular therapeutics are unable to cross the tight junctions, thereby limiting their bioavailability in the brain. Imprint ⦠One of the thinnest and strongest materials known to man, graphene is a 2D sheet of carbon just one atom thick. [ 22] in 2008, the first study on graphene for biomedical applications, a lot of interesting work has been carried out to explore the use of graphene for widespread biomedical applications, ranging from drug/gene delivery, biological sensing and imaging, antibacterial materials, to biocompatible scaffold ⦠Although a lot of work has demonstrated the successful delivery of anticancer drugs and genes using graphene-based nanomaterials as carriers, the correlations of their surface functionalization and size distribution and their therapeutic outcomes need more exploration. Nanocarriers capable of circumventing various biological barriers between the site of administration and the therapeutic target hold great potential for cancer treatment. Graphene and its derivatives are the latest materials to be designed for drug and gene delivery applications, including targeted delivery. Graphene Sheets and Nanocomposites Graphene sheets, the basic structural units of graphite and carbon nanotubes, are predicted to possess outstanding mechanical, electrical and thermal properties. Graphene oxide (GO) possesses excellent mechanical strength, biocompatibility, colloidal stability, large surface area and high adsorption capability. Some of the drug delivery occurs due to the change in temperature, pH, light ⦠Keywords:Cancer imaging, drug delivery, graphene oxide, nanocarrier. Motivated by the accomplishment of carbon nanotubes (CNTs), graphene and graphene oxide (GO) has been widely investigated in the previous studies as an innovative medication nanocarrier for the loading of a variety of therapeutics as well as anti-cancer medications, poor dissolvable medications, ant â¦. pH and Thermal Dual-Responsive Graphene Oxide Nanocomplexes for Targeted Drug Delivery and Photothermal-Chemo/Photodynamic Synergetic Therapy | ACS Applied Bio Materials. Then, Pue was transported across the BBB into the brain using lactoferrin (Lf) as the targeting ligand, which could bind to the vascular endothelial receptor on the BBB. Graphene for drug delivery. A biocompatible and cell traceable drug delivery system Graphene Quantum Dots (GQD) based, for the targeted delivery of the DNA intercalating drug doxorubicin (DOX) to cancer cells, is here reported. Graphene quantum dots have been shown to focus drug delivery on the cell nucleus and enhance the DNA cleavage activity of doxorubicin [31,32]. Since Graphene discovery, their associated derivate nanomaterials, Graphene Oxide (GO) and reduced-GO were in the forefront of continuous developments in bio-nano-technology due to unique physical-chemical properties. Graphene nanocomposite is a promising tool to address these drawbacks. As the 'bigger sister' of graphene, carbon nanotubes have been extensively explored in biomedicine since 2004, showing promising applications in ⦠The bloodâbrain barrier (BBB) is the protective sheath around the brain that protects the sensitive microenvironments of the brain. Comprehensive Review on Graphene Oxide for Use in Drug Delivery System. First Published 2018. Developed by Prof. Eijiro Miyako from JAIST (Nomi, Japan), Dr. Alberto Bianco from CNRS (Strasbourg, France), and their international teams, the multi-functional graphene drug delivery carriers are synthesized with different types of molecules such as near-infrared (NIR) fluorescent probe (indocyanine green; ICG), tumor targeting molecule (Folic acid: FA), and anticancer drug (doxorubicin; Dox) by a covalent chemical modification technique. Researchers at the North California State University, the University of North Carolina at Chapel Hill, and China Pharmaceutical University (CPU) developed a graphene-based drug delivery system for two anti-cancer drugs to cancer cells. Moreover, by taking advantage of the enhanced permeability and retention (EPR) effect of tumors, the use of Graphene as a drug nanocarrier for cancer treatment has the potential to passively deliver chemotherapeutic and metabolism altering agents to cancer populations with increased specificity, whilst minimizing dosage and side effects of the drugs. Incorporation of a small amount of graphene oxide (GO) in the biocompatible polymers for microneedle fabrication results in important new DPMN properties, that is, dramatically enhanced mechanic strength (10â17 times at 500 mg/mL ⦠Dissolvable polymeric microneedles (DPMNs) are promising transdermal drug delivery systems with minimal invasiveness and improved patient compliance. Graphene micro- and nano-particles have served as contrast agents for photoacoustic and thermoacoustic tomography. In this review, we introduce the development of graphene in biomedicine, from drug delivery, tumor therapy, to theranostics. It is for this reason that they have been targeted for many potential applications. Edition 1st Edition. Thus, the use of these nanoparticles in conjunction with known chemotherapies may lead to the reduction of the harmful high dose side effects of ⦠Muhammad Daniyal TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of ⦠The technique uses graphene strips to deliver the drugs, with each drug targeting the distinct part of the cell where it will ⦠The present study aimed at incorporating GO in buccal polyelectrolyte films for delivery of antifungal drugs and investigating the effect of GO on the film properties and drug release profiles, as well as antifungal activities. 2014 Aug;3(8):1334-43. doi: 10.1002/adhm.201400016. Graphene has been also known to have a good biocompatibility and biodegradability, thus leading researchers to explore this nanocarbon as drug delivery carrier. 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